Exploration of Medicine

Table 2. Clinicopathologic characteristics of patients with positive cfDNA plasma test results by methylation status of SDC2 and SEPT9 markers

Variable	All	Combined test positive (n = 78)	*No. of mSDC2* positive (n = 69)**	*No. of mSEPT9* positive (n = 30)**
Age (years)
≤ 49	108	19 (24.4%)	18 (26.1%)	9 (30.0%)
50–59	60	20 (25.6%)	16 (23.2%)	7 (23.3%)
60–69	60	25 (32.1%)	23 (33.3%)	7 (23.3%)
≥ 70	25	14 (17.9%)	12 (17.4%)	7 (23.3%)
Gender
Male	83	28 (35.9%)	25 (36.2%)	13 (43.3%)
Female	170	50 (64.1%)	44 (63.8%)	17 (56.7%)
Location
Proximal colon	70	33 (47.1%)	28 (45.2%)	18 (66.7%)
Distal colon	68	37 (52.9%)	34 (54.8%)	9 (33.3%)
CRC stage
I + II	8	8	8	6
III + IV	10	10	9	6
Histological classification
Advanced adenoma	14	11	9	5
Serrated lesions	17	10	10	4
Non-advanced adenoma	57	19	17	4
Hyperplastic polyps	19	8	5	3

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Supplementary materials

The supplementary figure for this article is available at: https://www.explorationpub.com/uploads/Article/file/1001322_sup_1.pdf. The supplementary table for this article is available at: https://www.explorationpub.com/uploads/Article/file/1001322_sup_2.xlsx.

Declarations

Author contributions

V Borobova: Formal analysis, Investigation, Software, Visualization, Writing—original draft. AA: Data curation, Resources. DS: Data curation, Methodology. V Baklaushev: Resourses. DI: Resources, Investigation. EV: Investigation, Data curation. AV: Methodology. NO: Data curation. PL: Methodology, Project administration, Supervision, Writing—review & editing. SK: Conceptualization, Validation. All authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This study was approved by the ethics committee of the Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical and Biological Agency of Russia, Moscow (Protocol No. 5_2024, 04.06.2024). Biopsy material was obtained in compliance with the legislation of the Russian Federation, and written informed consent was provided by all the patients.

Consent to participate

Informed consent to participate in the study was obtained from all participants.

Consent to publication

Informed consent to publication was obtained from relevant participants.

Availability of data and materials

The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

Funding

Not applicable.

Copyright

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