Main demographic, diseases and therapeutic characteristics, and diagnostic and surgical interventions in the study population with DFS
| Characteristics | Mean value ± SD |
|---|---|
| Sex Males (%) | 73.3 |
| Age (years) | 70.9 ± 10.35 |
| Age of onset of T2D (years) | 49.2 ± 15.5 |
| Duration of diabetes (years) | 19.2 ± 16.3 |
| BMI (Kg/m2) | 30.2 ± 7.6 |
| Systolic Blood Pressure (mmHg) | 143.7 ± 20.5 |
| Diastolic Blood Pressure (mmHg) | 75.5 ± 10.9 |
| Heart Rate (bpm) | 80.4 ± 14.4 |
| Glasgow Come Scale (0–15) | 14.9 ± 0.3 |
| Pain scale (NRS 0–10) | 2.6 ± 3.4 |
| Body Temperature (°C) | 36.5 ± 0.7 |
| Co-morbidity at admission | Frequency (%) |
| Heart failure | 17.8 |
| Soft tissue inflammation | 82.7 |
| Osteomyelitis | 56 |
| PAD | 76 |
| Retinopathy | 40.5 |
| CKD (no. of patients) | 48 |
| Stage IIIa (eGFR 59-45 mL/min) | 20 |
| Stage IIIb (eGFR 44-30 mL/min) | 12 |
| Stage IV (eGFR 29-15 mL/min) | 12 |
| Stage V (eGFR < 15 mL/min) | 4 |
| Ischemic Heart Disease | 50 |
| Atrial Fibrillation | 14.7 |
| Previous Stroke | 13.3 |
| Active cancer | 5.4 |
| Dementia | 4 |
| Hepatic Steatosis | 16 |
| COPD | 6.7 |
| Smokers | 12.3 |
| Therapy at admission | Frequency (%) |
| Anti-hypertensive | 74.7 |
| Oral antidiabetics | 56.8 |
| Insulin | 54.1 |
| Antiplatelet agents | 64.4 |
| Statins | 54.1 |
| Primary Endpoints | Frequency (%) |
| Lower limb amputation (total 21 patients) | 28.4% |
| Major: 4.1% | |
| Minor/Curative: 24.3% | |
| Mortality in Diabetic Foot Unit (no patient) | 0% |
| Secondary Endpoints | Mean value ± SD |
| In-hospital duration of antibiotic therapy (days) | 18 ± 9.8 |
| Total duration of antibiotic therapy (days) | 23.9 ± 15.9 |
| Time of hospital stay (days) | 18.4 ± 7.9 |
| Others | Frequency (%) |
| Percutaneous angioplasty | 41.3% |
| Transfer to Intensive Care Unit (total 4 patients) | 5.3% |