A summary of AS1411-functionalized chemotherapeutic drug delivery nanosystems for targeted cancer therapy
| Delivery system | Components | Drug(s) | Animal models or/and cells lines | Investigated cancer type | In vivo/in vitro | Reference |
|---|---|---|---|---|---|---|
| NP | PLGA-Lecithin-PEG | PTX | MCF-7, GI-1 | Breast cancer and gliosarcoma | In vitro | [59] |
| NP | MF-NR-PLGA | PTX | MCF-7 | Breast cancer | In vitro | [60] |
| NP | PEG-PCL | Docetaxel | BALB/c mice & BALB/c nude mice/C6, bEnd.3 | Glioma | In vivo/in vitro | [61] |
| NP | PLGA-PEG-COOH | PTX | C6 glioma xenograft mice, intracranial C6 glioma rats | Glioma | In vivo | [62] |
| NP | pPEGMA-PCL-pPEGMA | DOX | MCF-7, PANC-1 | Epithelial cancer | In vitro | [63] |
| NP | HSA | PTX | MCF-7 | Breast cancer | In vitro | [64] |
| NP | PLGA-PEG | Vinorelbine | MDA-MB-231 | Breast cancer | In vitro | [65] |
| NP | Cytochrome C capped mesoporous silica NPs | DOX | Athymic BALB/c nude mice/HepG2 | Hepatocellular carcinoma | In vivo/in vitro | [66] |
| Nanosphere | Colloidal gold nanospheres | - | Fox1nu nude mice/MCF-7 & MDA-MB-231 | Breast cancer | In vivo/in vitro | [67] |
| Nanostar | Gold nanostar | - | Nude mice, Sprague-Dawley (SD) rats/HT-1080, MDA-MB-231 | Fibrosarcoma, breast cancer | In vivo/in vitro | [68] |
| Drug-DNA adduct | - | DOX | NOD.Cg-PrkdcSCID IL2 mice/Huh7 | Hepatocellular carcinoma | In vivo/in vitro | [69] |
| Nanotube | SWCNT | DOX | BALB/c nude mice/PC3 | Prostate cancer | In vivo/in vitro | [70] |
| Micelles | Pluronic F127, β-CD-PELA | DOX | BALB/c nude mice/MCF-7 | Breast cancer | In vivo/in vitro | [47] |
| Micelles | TPGS-b-PBAE | PTX | BALB/c nude mice/SKOV3 | Ovarian cancer | In vivo/in vitro | [52] |
| Capsule | Cell membrane capsules | DOX hydrochloride | BALB/c nude mice/QGY-7703 | Liver cancer | In vivo/in vitro | [71] |
| Micelles | PEG-PAE | DOX | MCF-7 | Breast cancer | In vitro | [53] |
MF: magnetic fluorescence; NR: Nile red; PCL: polycaprolactone; pPEGMA: poly(polyethylene glycol methacrylate); SWCNT: single walled carbon nanotubes; PBAE: blockpoly-(β-amino ester)