List of on-going nano based clinical trials for cancer immunotherapy
| S. No | Title of the study | Nano-particle used | Target | Developer | Clinical stage | Clinical trial code/Ref |
|---|---|---|---|---|---|---|
| 1 | A randomized, double-blind, placebo controlled phase III study to investigate efficacy and safety of first-line treatment with HLX10 + chemotherapy (carboplatin-nanoparticle albumin bound (nab) paclitaxel) in patients with stage IIIB/IIIC or IV NSCLC | Albumin | Squamous non-small cell lung lancer | Shanghai Henlius Biotech | Phase 3 | NCT04033354 |
| 2 | A study to evaluate safety/tolerability of immunotherapy combinations in participants with triple-negative breast cancer or gynecologic malignancies | Albumin | Breast cancer, ovarian cancer | Arcus Biosciences, Inc., Infinity Pharmaceuticals, Inc. | Phase 1 | NCT03719326 |
| 3 | Bispecific antibody armed activated T-cells with aldesleukin and sargramostim in treating patients with locally advanced or metastatic pancreatic cancer | Albumin | Metastatic pancreatic adenocarcinoma, pancreatic carcinoma | Barbara Ann Karmanos Cancer Institute, National Cancer Institute (NCI) | Phase 1, 2 | NCT02620865 |
| 4 | NBTXR3 activated by radiation therapy for the treatment of locally advanced or borderline-resectable pancreatic cancer | Hafnium oxide | Borderline resectable pancreatic adenocarcinoma, locally advanced pancreatic ductal adenocarcinoma, resectable pancreatic ductal adenocarcinoma | M.D. Anderson Cancer Center, NCI | Phase 1 | NCT04484909 |
| 5 | Investigating the effects of Mikei® red reishi essence EX on the immune system of prostate cancer patients and patients with non-cancerous conditions of the prostate | Gold | Prostate cancer | Nikkei (Canada) Marketing Limited | NA | NCT03589781 |
| 6 | IMX-110 in patients with advanced Solid tumors | NA | Solid tumor, advanced solid tumors, pancreatic cancer, breast cancer, ovarian oancer | Immix Biopharma Australia Pty Ltd, Immix Biopharma, Inc. | Phase 1, 2 | NCT03382340 |