ACE2/Ang-(1-7)/MasR axis on stress behavior and anxiety
| Central area | Animal model | Main effects | Reference |
|---|---|---|---|
| Cerebral ventricles | Ang-(1-7) acute injection to rats | - First evidence of an anxiolytic action of Ang-(1-7) | Holy et al., 1992 [146] |
| TGR(ASrAOGEN)680R rats (rats with low brain AGT, expressing an antisense RNA against AGT in glial cells) | - Ang-(1-7) acute injection prevented the anxiety- and depressive-like behavior in transgenic rats | Kangussu et al., 2013 [104] | |
| Conscious male Wistar rats with induced tachycardia by acute stress (air jet 10 l/min) | - Ang-(1-7) acute injection decreased by ~45% the tachycardia induced by emotional stress | Lima et al., 2013 [83] | |
| Transgenic hypertensive (mRen2)27 rats | - Ang-(1-7) infusion promoted anxiolytic effects- Beneficial effects of Ang-(1-7) were mediated by MasR | Almeida Santos et al. 2016 [147] | |
| C57BL/6 mice with enhanced ACE2 activity by central delivery of diminazene aceturate (ACE2 activator) | - ACE2 activation reduced anxiety-like behavior- Beneficial effects of ACE2 activation were mediated by MasR | Wang et al. 2016 [149] | |
| Amygdala | Adult male Wistar rats | - Ang-(1-7) acute injection induced anxiolytic effects- Ang-(1-7) increased GPx specific activity and decreased the main peroxidation marker MDA- The majority of the behavioral parameters correlated with markers of oxidative stress | Bild et al., 2013 [145] |
| Wistar rats submitted to stress trials | - Ang-(1-7) prevented the tachycardia and the pressor response induced by acute stress- Beneficial effects of Ang-(1-7) were mediated by MasR | Oscar et al., 2015 [121] | |
| Hippocampus | Mas–/– mice | - Mas-deficient animals showed increased anxiety | Walther et al., 1998 [148] |
GPx: glutathione peroxidase; MDA: malondialdehyde