Exploration of Medicine

Table 2

Sarcolemmal activities of Na⁺-Ca²⁺ exchange and N⁺-K⁺ ATPase as well protein content and mRNA levels of N⁺-K⁺ ATPase in control and MI animals with or without ENP and LOS treatments for 4 weeks starting at 3 weeks after induction of MI

Parameters	Control	MI	MI + ENP	MI + LOS
A. SL activities
Na⁺-Ca²⁺ exchange activity (nmol Ca²⁺ mg/2s)	8.2 ± 0.51	3.8 ± 0.26^*	7.4 ± 0.45^†	7.0 ± 0.21^†
Na⁺-K⁺-ATPase activity (μmol Pi/mg per h)	22.1 ± 0.82	12.9 ± 0.64^*	18.3 ± 0.59^†	18.6 ± 0.84^†
B. Na⁺-K⁺-ATPase isoform protein content (% of control)
α2	100	79.6 ± 3.4^*	89.9 ± 1.6^†	92.9 ± 2.5^†
α3	100	134.0 ± 5.2^*	114.7 ± 4.2^†	113.6 ± 5.5^†
β2	100	73.6 ± 3.1^*	98.6 ± 8.5^†	99.2 ± 8.5^†
β3	100	66.8 ± 1.6^*	81.1 ± 4.5^†	90.3 ± 6.7^†
C. Na⁺-K⁺-ATPase isoform mRNA level (% of control)
α1	100	107.5 ± 2.5	110.2 ± 4.8	112.2 ± 4.5
α2	100	72.9 ± 2.1^*	86.3 ± 3.6^†	85.5 ± 4.5^†
α3	100	170.5 ± 9.5^*	116.2 ± 4.8^†	115.3 ± 14.8^†
β1	100	110.7 ± 7.2	120.5 ± 6.5	120.2 ± 7.5

Return to article view

Values are mean ± SE of 6 animals in each group. Data are based on the analysis of the information in our papers Shao et al. Am J Physiol Heart Circ Physiol. 2005;288:H2637–46 [116] and Guo et al. Can J Physiol Pharmacol. 2008;86:139–47 [131]. ^*P < 0.05 compared with control; ^†P < 0.05 compared with MI group