From:  Oxidative stress in obesity and insulin resistance

AOS in obesity and IR in animal model studies

Animal tissue/cell typeComponents of AOS defenseEffect of obesity/IRRef
3T3-L1 adipocytes of miceEC-SOD expressionIncreased[75]
Perirenal, epididymal, and brown adipose tissues of male Wistar ratsSOD, CAT, GPx activitiesDecreased[82]
Liver of male C57BL/6 miceMn-SOD protein levelDecreased[29]
Heart of male C57BL/6J miceCAT protein level/CAT activityIncreased[76]
Visceral adipose tissue of female Wistar ratsMn-SOD, GPx protein levels/Cu/Zn-SOD, GR protein levelsDecreased/unchanged[81]
Primary hepatocytes of male C57BL/6J miceGSH content, GPx, and GR activitiesDecreased[31]
Soleus muscle of Wistar male ratsTotal GSH level/Mn-SOD, CAT, GPx expressionDecreased/unchanged[77]
Plasma samples and heart of male fa/fa ZRSOD/GPx activitiesDecreased/unchanged[30]
Serum of male Albino ratsMDA level/GSH levelIncreased/decreased[83]
White adipose tissue of female Wistar ratsSOD1 and GR protein levelsIncreased[78]
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