AOS in obesity and IR in human studies
| Human tissue/cell type | Components of AOS defense | Effect of obesity/IR | Ref |
|---|---|---|---|
| Serum of obese women | GPx activity | Decreased | [85] |
| Plasma of obese children of both sexes | Zn concentration | Decreased | [93] |
| Serum of morbidly obese male and female patients | Vitamins A, B6, C, D, E concentrations | Decreased | [95] |
| Serum of obese adolescents | Se concentration | Decreased | [92] |
| Erythrocytes of obese women | Cu/Zn-SOD, CAT, GPx activities | Decreased | [86] |
| Serum of male and female T2DM patients | GSH content/GPx, GR activities | Decreased | [32] |
| Adipose tissue of obese and/or T2DM male and female patients | Mn-SOD, GPx activities | Decreased | [87] |
| Serum and liver of male and female NAFLD patients | GSH level | Decreased | [33] |
| Peripheral blood mononuclear cells of obese children of both sexes | Mn-SOD, CAT expression | Decreased | [34] |
| Serum of MS male and female patients | Vitamin E concentration | Decreased | [96] |
| Blood samples of obese and overweight children | SOD activity/GSH/GSSG ratio, CAT activity | Increased/decreased (in obese); all decreased (in overweight) | [88] |
| Blood samples of MS male and female patients | Vitamin C, GSH levels | Decreased | [89] |
NAFLD: non-alcoholic fatty liver disease