Association of incident LBBB with clinical endpoints in multivariate Cox regression models
| Endpoint | No new LBBB, n (%) | Incident LBBB, n (%) | HR (95% CIs) | P |
|---|---|---|---|---|
| Primary composite endpoint | 988 (25.8) | 28 (19.7) | 1.91 (1.26–2.88) | < 0.001 |
| Stroke | 502 (12.9) | 6 (4.0) | 0. 66 (0.36–1.20) | 0.655 |
| Myocardial infarction | 360 (9.2) | 5 (3.3) | 1.06 (0.43–2.62) | 0.893 |
| CV mortality | 364 (9.0) | 21 (13.2) | 3.04 (1.83–5.05) | < 0.001 |
| Sudden cardiac death | 564 (14.6) | 7 (4.8) | 1.26 (0.82–1.93) | 0.294 |
| Hospitalization for heart failure | 264 (6.7) | 12 (8.4) | 3.55 (1.90–6.64) | < 0.001 |
| All-cause mortality | 705 (17.7) | 34 (21.6) | 2.97 (2.04–4.33) | < 0.001 |
Adjusted for diabetes, isolated systolic hypertension, prevalent CV disease, Framingham risk score, randomized treatment assignments and degree of ECG-LVH at baseline as fixed covariates, and incident LBBB, ECG-LVH by Cornell voltage and diastolic and systolic blood pressures obtained on LIFE study follow-up examinations as time-varying covariates. All-cause mortality was considered as a competing end-point for outcomes including non-fatal events