Time varying Cox-regression models for EF reduction
| A. Preliminary model | |||
|---|---|---|---|
| Variable | HR | 95% CI | P |
| Clinical propensity score | 1.02 | 0.99–1.09 | 0.251 |
| Treatment arm (losartan) | 0.74 | 0.37–1.52 | 0.414 |
| Baseline EF (%) | 0.88 | 0.20–0.95 | 0.001 |
| In-treatment systolic BP (mmHg) | 0.98 | 0.97–1.01 | 0.083 |
| B. Final model | |||
|---|---|---|---|
| Variable | HR | 95% CI | P |
| In-treatment heart rate (10 beats/min) | 1.3 | 1.1–1.5 | 0.004 |
| Baseline EF (%) | 0.95 | 0.88–1.02 | 0.152 |
| In-treatment LV diameter (cm) | 5.19 | 2.58–10.41 | 0.0001 |
| In-treatment mitral E/A ratio (per unit) | 2.37 | 1.58–3.56 | 0.0001 |