From:  Reactive oxygen species in cardiovascular diseases: an update

Response of ROS under different mechanisms in cardiovascular diseases

Disease typesROSMechanismsPMIDsPublication dates
I/R↑Ripk3–Ca2+ overload–XO–ROS295020452018-02
↓HIF-1–NADPH–mtROS347638602022-02
↓AMPK–Akt–GSK-3β–ROS281283612017-01
↓TAK1↓–ROS323782872020-10
↓GJA1-20k–ROS346088632021-10
↓PHLDA1–ROS319816282020-03
Hypertension↓JMJD1A–ROS324619962020-05
↓AMPK–PAR1–ROS292877252018-01
↓AMPK–PINK1–parkin–ROS292856902018-03
↓AMPK–O-GlcNAC↓–ROS292856902018-01
↓Sirt1–LKB1–MAPK–ROS237075582013-10
↓Foxo1–SOD2–ROS306775122019-06
↓ROS–Nrf2–ARE–ROS336569042020-12
↑AngII–ROS306439682019-01
↓CELF1↓–PEBP1–MAPK↓–ROS346690212022-01
Atherosclerosis↓IRS-1–ROS330002672020-11
↑HIF-1–ROS351110452021-12
↓PON2–ROS174041542007-04
↑AMPK–NOX↓–ROS313311112019-07
↓PKM2↓–G6P–NADPH–ROS302221362018-10
↓Sirt3–Foxo3α–MnSOD–ROS236653962013-10
↓Sirt3–IDH2–GSH–ROS304553812019-01
DCM↑RAGE–NOX–ROS279166502017-04
↑PKC–NF-κB–iNOS–ROS279166502017-04
↑NEU1–AMPKα↓–Sirt3↓–SOD2↓–ROS350025282022-01
Heart failure↑Sirt3–CypD–mPTP–SOD↓–ROS335084342021-03
Vascular endothelial↓Sirt2–Foxo3α–SOD–ROS340281772021-07
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AngII: angiotensin II; ARE: antioxidant response element; CELF1: cytimidine uracil guanine triplet repeat-binding protein 1; CypD: cyclophilin D; Foxo1: forkhead box protein O1; Foxo3α: forkhead box transcription factor 3α; G6P: glucose-6-phosphate; IDH2: isocitrate dehydrogenase 2; IRS-1: insulin receptor substrate 1; JMJD1A: Jumonji domain containing 1A; LKB1: liver kinase B1; MAPK: mitogen-activated protein kinases; MnSOD: manganese SOD; NEU1: neuraminidase 1; NF-κB: nuclear factor kappaB; Nrf2: nuclear factor E2-related factor 2; O-GlcNAC: O-linked N-acetylglucosamine; PAR1: protease-activated receptor 1; PEBP1: phosphatidylethanolamine binding protein 1; PINK1: phosphatase and tensin homolog-induced putative kinase 1; PKC: protein kinase C; PKM2: pyruvate kinase M2; PON2: paraoxonase-2; RAGE: receptor for advanced glycation end products; Ripk3: receptor-interacting serine/threonine-protein kinase 3; Sirt 1: sirtuin 1; PMID: PubMed ID; ↑: increase; ↓: decrease