A partial list of anticancer drugs based on increased ROS production
| Drug (name) | Cancer treated | Mechanism to increase ROS | References |
|---|---|---|---|
| Platinum drugs | Breast cancer (in combination with PARP inhibitors) | ROS-dependent DNA damage | [8, 9] |
| Imatinib | Melanoma | Loss of mitochondrial membrane potential | [10] |
| Doxorubicin | Kaposi’s sarcoma, breast, and bladder cancer | Fenton’s reaction and electron leakage | [11] |
| 5-Fluorouracil | Colon and rectal cancer | P53 dependent ROS | [12, 13] |
PARP: poly (ADP-ribose) polymerase