Exploration of Targeted Anti-tumor Therapy

S/N	Methods	Solvent	Concentrations	Major findings	Reference
1	In vivo	Ethanol and aqueous	500, 800, 1,000, and 1,300 mg/kg	The ethanol and water extract of FDK lowers blood pressure in SHR. This could be due to RAAS, antioxidant, and endothelial systems	[93]
2	In vivo	Ethanol-water	800 or 1,000 mg/kg/day	When FDA and losartan were used to treat rats, the rats’ blood pressure, heart rate, and heart weight were all much lower than the controls	[94]
3	In vivo		1,000 mg/kg/day	After four weeks of treatment with FD, the SBP of rats treated with FD and losartan was much lower than that of rats that were not treated. An analysis of the spectra of urine showed that there were 24 possible biomarkers with variable importance projections above 0.5	[95]
4			1,000 mg/kg	Compared to the control group, rats treated with 1,000 mg/kg of FD and losartan demonstrated a significant decrease in blood pressure. Rats treated with FDK had decreased serum concentrations of angiotensin II and aldosterone compared to controls and rats treated with losartan. There were no variations between serum and urine electrolytes	[96]

S/N

Methods

Solvent

Concentrations

Major findings

Reference

In vivo

Ethanol and aqueous

500, 800, 1,000, and 1,300 mg/kg

The ethanol and water extract of FDK lowers blood pressure in SHR. This could be due to RAAS, antioxidant, and endothelial systems

[93]

In vivo

Ethanol-water

800 or 1,000 mg/kg/day

When FDA and losartan were used to treat rats, the rats’ blood pressure, heart rate, and heart weight were all much lower than the controls

[94]

In vivo

1,000 mg/kg/day

After four weeks of treatment with FD, the SBP of rats treated with FD and losartan was much lower than that of rats that were not treated. An analysis of the spectra of urine showed that there were 24 possible biomarkers with variable importance projections above 0.5

[95]

1,000 mg/kg

Compared to the control group, rats treated with 1,000 mg/kg of FD and losartan demonstrated a significant decrease in blood pressure. Rats treated with FDK had decreased serum concentrations of angiotensin II and aldosterone compared to controls and rats treated with losartan. There were no variations between serum and urine electrolytes

[96]