Exploration of Targeted Anti-tumor Therapy

Table 2. Details of the anticancer efficacy of BD in several human malignancies using in vivo models

Cancer type	Model used	Dose	Duration	Measurement frequency	Route of administration	Observed effects	Mode of action	References
NSCLC	A549 cells in BALB/c-nu mice	40 mg/kg/day	15 days	Every 2 days	Intraperitoneal injection	↓Tumour growth	↑pJNK, ↑caspase 9 ↑Apoptosis; ↑LC3-II, ↑Autophagy	[28]
Osteosarcoma	MNNG/HOS cells in BALC/c-nu mice	2.5 mg/kg/2 days; 5.0 mg/kg/2 days	12 days	Every 2 days	Intraperitoneal injection	↓Tumour size ↓Tumour weight	↓pSTAT3, ↓MMP2 and MMP9, ↓Ki67	[47]
Hepatocellular carcinoma	Huh7 cells in BALC/c-nu mice	0.75 mg/kg/day; 1.5 mg/kg/day	10 days	Daily	Intravenous tail vein injection	↓Tumour growth	↑Proteasome, ↓Total β-catenin, ↓Active β-catenin, ↓JAG1, ↓NICD, ↑Apoptosis	[45]

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MMP2: matrix metalloproteinase-2 (gelatinase A); MMP9: matrix metallopeptidase 9 (gelatinase B)

Declarations

Author contributions

The concept and design of this manuscript are conceived by ZWS and MG. ZWS, AKP, and MG wrote and revised the manuscript, presented the concept, created figures, tables. All authors have read the manuscript and agreed to the published version of the manuscript.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

This work was supported by the Department of Biotechnology (DBT), under its Ramalingaswami Fellowship number BT/RLF/Re-entry/24/2014 and Science and Engineering Research Board under its ECRA scheme (SERB File No. ECR/2016/001519) award to Dr. Manoj Garg. The sponsor(s) have no role in designing, analysis, interpretation and writing.

Copyright

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