Involvement of gut microbiota dysbiosis in CRC
| Phyla and species concerned by dysbiosis in CRC | Reference |
|---|---|
| Infection with S. bovis a risk factor for colon tumors | [52] |
| High enrichment of Fusobacteria in colorectal carcinoma tissue | [53] |
| ETBF, and Fusobacterium nucletum are highly expressed in CRC tissue | [54] |
| Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients; Lactococcus and Fusobacterium is more abundant while Pseudomonas and Escherichia-Shigella reduced in cancerous tissues versus adjacent tissues | [55] |
| Mucosa-associated E. coli of the B2 phylogroup more prevalent in CRC tissues | [56] |
| Fusobacterium nucleatum isolated from tumor tissue and proved to be invasive in the in vitro experiments | [57] |
| B. fragilis, Enterococcus Escherichia-Shigella, Klebsiella, Streptococcus, and Peptostreptococcus is abundant in CRC patients, while Roseburia- and Lachnospiraceae-related OTUs more abundant in healthy controls | [58] |
| CRC patients have a lower microbiota diversity and Clostridia abundance, with a high abundance of Fusobacterium and Porphyromonas at the genus level | [59] |
| Bifidobacterium, Faecalibacterium, and Blautia reduction, while Fusobacterium enrichment in the CRC patients; stool samples in CRC patients enriched with Paraprevotella, Eubacterium | [60] |
| Association of Clostridioides difficile with CRC revealed by anti-tcdB antibodies in plasma, particularly the IgA level; anti-tcdB antibodies as candidate serologic markers for CRC | [61] |
| Bacteroidetes cluster 1 and Firmicutes cluster 1 decreased in CRC mucosa, whereas Bacteroidetes cluster 2, Firmicutes cluster 2, pathogen cluster, and Prevotella cluster increased in CRC mucosa; compositional alterations in the microbiota differ between distal and proximal cancers | [62] |
S. bovis: Streptococcus bovis; ETBF: enterotoxigenic Bacteroides fragilis; E. coli: Escherichia coli; F. nucleatum: Fusobacterium nucleatum; B. fragilis: Bacteroides fragilis; OTUs: operational taxonomic units; tcdB: clostridium difficile toxin B; IgA: immunoglobulin A