Biological evaluation of Syzygium aqueum (Burm.f.) Alston against several cancer cell lines
| N | Parts of the plant | Solvents | Concentration | Type of cancer | Major finding | Reference |
|---|---|---|---|---|---|---|
| 1 | Stem bark (oleanolic acid and b-sitosterol) | Methanol | 100 μL | Cervical, breast | It was found compound one to be significant against the tested cell line while compound 2 was only on HeLa cell line | [30] |
| 2 | Leaves (essential oils) | Dimethyl sulphoxide | 1% | Breast | As measured by an IC50 value of 76.40 μg/mL, it exhibited modest activity against the MCF-7 cell line | [31] |
| 3 | Stem bark | Methanol | 1.5625–100 μg/mL | Cervical, breast, lung | The IC50 values for alphitolic acid were 16.12 mg/mL and 7.37 mg/mL, indicating that it was toxic to the HeLa and T47D cell lines. A549 cells were inhibited to a modest degree (IC50 = 84.41 μg/mL), nevertheless. Arjunolic acid was also discovered to be toxic to HeLa cell lines, having an IC50 of 6.74 μg/mL | [28] |
| 4 | Fruits | Aqueous, methanol | - | Breast cancer cell line | Aqueous extracts revealed antiproliferation effects on MCF-7 cell lines (P < 0.05) after 72 h, however, the effects were insignificant on a non-cancer-origin cell line and were not seen in the 24-h or 48-h time periods | [29] |
| 5 | Leaves | Methanol | 0.01, 0.1, 1, 10, and 100 μg/mL | Breast | At 100 μg/mL, Syzygium aqueum was observed to significantly (P < 0.05) boost MCF-7 cell growth | [32] |
| 6 | Stem bark | Methanol | 100 μL | Cervical, breast cancer | Butyrospermol was only moderately cytotoxic (43.59 μg/mL) against the HeLa cell line and barely cytotoxic at all against the T45D and A549 cell lines. And when tested with the 2,3-bis [2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) assay, sitosterone (29.96 μg/mL) exhibited considerable toxicity towards the A549 cell line | [33] |
| 7 | - | - | 50 μg/mL and 100 μg/mL | Fibroblasts, breast | In addition, neither the ethanolic nor the aqueous extracts showed any antiproliferative effects on 4T1 or 3T3 cells at 50 μg/mL or 100 μg/mL | [34] |
-: not applicable