Exploration of Targeted Anti-tumor Therapy

N	Parts of the plant	Solvents	Concentration	Type of cancer	Major finding	Reference
1	Leaves	Methanol	15.63–1,000 μg/mL	Breast	With IC₅₀ values of 672 μg/mL and 126 μg/mL against 4T1 and MCF-7 cells, respectively, the extract displays a weak cytotoxic impact.	[82]
2	Leaves	Aqueous	-	-	The cell cycle arrest of HB4C5 is induced by the crude extract between G1 and S phase.	[83]
3	Ripened and unripe fruits, leaves	Ethanol	-	-	Fruit and leaf extracts were found to be ineffective (LC₅₀ > 1,000 μg/mL).	[84]

Parts of the plant

Solvents

Concentration

Type of cancer

Major finding

Reference

Leaves

Methanol

15.63–1,000 μg/mL

Breast

With IC₅₀ values of 672 μg/mL and 126 μg/mL against 4T1 and MCF-7 cells, respectively, the extract displays a weak cytotoxic impact.

Leaves

Aqueous

The cell cycle arrest of HB4C5 is induced by the crude extract between G1 and S phase.

Ripened and unripe fruits, leaves

Ethanol

Fruit and leaf extracts were found to be ineffective (LC₅₀ > 1,000 μg/mL).