Exploration of Targeted Anti-tumor Therapy

Table 1.

Selected anticancer effects of SAB on tumor cell lines

Type of cancer	Model/cell line	Morphological effects	Mechanisms of action	References
Oral cancer	CAL27, SCC4, Leuk1	Apoptosis, inhibits cell growth, anti-angiogenesis	↓HIF-1α, ↓TNFα, ↓MMP9, ↓Tenascin-C, ↓Osteopontin, ↓TGFβ, ↓Cox-2, ↓HGF, ↓MMP2, ↑THBS2	[75, 76]
Oral cancer	CAL27, HN4, and Leuk1	Apoptosis, inhibits cell growth, modulates Warburg effect	↓MMP, ↓PI3K/Akt/HIF-α	[123]
Leukemia	HL-60	Apoptosis, inhibits cell growth	-	[125]
Cervical cancer	Hela cells SAB + ATO	Apoptosis, inhibits cell growth	↓pro-caspase 3, ↑PARP cleavage	[96]
Retinoblastoma	HXO-RB44	Apoptosis, cell volume shrinkage, chromatics agglutination, inhibits cell growth, cell cycle arrest at S phase	↑caspase 3	[117]

↑ increases expression, ↓ decreases expression