Exploration of Targeted Anti-tumor Therapy

Table 2.

Selected in vivo anticancer effects of SAB

Type of cancer	Mouse/mice/hamster model	Morphological effects	Mechanism(s) of action	References
Breast cancer	Mouse model	Apoptosis induction, reduction of oxidative stress, anti-inflammatory, anti-angiogenesis	↓MMp-8, ↓TNF, ↓COX-2, ↓p53, ↑caspase 3	[83]
Breast cancer	Mouse model	Increased cell apoptosis, inhibition of growth	↓PCNA, ↓Survivin, ↓BCL-XL	[84]
Colon cancer	LoVo cells HCT-116 cells nude mice	Inhibits tumor growth, inhibits tumor invasion, multidrug resistance	↓CD44, ↓CD133, ↓SOX-2, ↓ABCG2	[108]
Colon cancer	BALB/c nude mice injected with HCT116 cells	Pro-death autophagy	↑Atg5 expression, ┴AKT/mTOR signaling pathway, ↓p70S6K	[63]
Glioma	U87 xenograft nude mice	Tumor volume reduced, weight reduced, increases ROS	↑p38, ↑p53	[111]
Oral cancer	Hamster	Antiproliferative, inhibition of angiogenesis	↓HIF-1α, ↓VEGF	[122, 123]
Head and neck cancer	JHU-013 xenograft mouse	Apoptosis, anti-proliferative, angiogenesis	↓COX-2	[57, 58]

↑ increase expression, ↓ decrease expression, ┴ inhibit