From:  Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers

Selection of significantly differentially expressed genes that correspond to the characteristics of tumors

GenesFunction in tumor cellsLog2 fold changeP adjustedReference
WNT5aOncogen and tumor suppressor, associated with invasion, proliferation, and EMT5.7110.001[82]
MMP3Associated with metastasis5.3140.002[83]
SOX2Associated with tumor growth and metastasis5.2320.005[84]
TMPRSS4Associated with tumor proliferation and metastasis5.1530.002[85]
FOXE1Associated with tumor growth4.9490.020[86]
FOXQ1Associated with metastasis4.8820.005[87]
TNCAssociated with metastasis and EMT4.6530.002[88]
TBX2Associated with tumor proliferation4.5080.007[89]
CRYABAntiapoptotic factor4.4740.007[90]
MMP2Associated with metastasis4.2490.002[83]
PTHLHAssociated with tumor growth4.2440.041[91]
EMP2Associated with angiogenesis4.2110.001[92]
CCN1Associated with tumor growth4.2030.006[93]
SPP1Associated with tumor growth and metastasis4.1960.018[94]
GPNMBAssociated with metastasis4.0640.003[95]
ANO1Associated with metastasis4.0280.014[96]
MMP12Associated with metastasis3.9520.083[83]
YAP1Associated with tumor growth3.8700.001[97]
MMP13Associated with metastasis3.8320.077[83]
SNAI2Associated with EMT and metastasis3.8130.012[98]
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EMT: epithelial mesenchymal transition; MMP3: matrix metalloproteinase 3; SOX2: SRY-box transcription factor 2; TMPRSS4: transmembrane serine protease 4; FOXE1: forkhead box E1; TNC: tenascin C; TBX2: T-box 2; CRYAB: crystallin alpha B; PTHLH: parathyroid hormone like hormone; EMP2: epithelial membrane protein 2; CCN1: cellular communication network factor 1; SPP1: secreted phosphoprotein 1; GPNMB: glycoprotein nmb; ANO1: anoctamine 1; YAP1: Yes associated protein 1; SNAI2: snail family transcriptional repressor 2