From:  Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential

All ongoing oncology clinical trials involving the removal of soluble TNFR

Cytokine Clinical trial IDPhaseNumber of patientsCancer typeTreatmentStatusEstimated study completion date
TNFαNCT04004910I/II170Advanced breast cancerThree-way comparison between plasma soluble TNFR pulldown with or without chemotherapy, and chemotherapy aloneRecruitingJuly 2023
TNFαNCT04142931I30Stage IV non-small cell lung cancer, stage IV melanoma, triple-negative breast cancer, or stage IV renal cell carcinomaReduction of soluble TNFR, with or without nivolumabRecruitingDecember 2022
TNFαNCT04690686II24Non-small cell lung cancerReduction of soluble TNFR alone, or with atezolizumab or paclitaxelRecruitingDecember 2022