Exploration of Targeted Anti-tumor Therapy

Medication	Mechanism of action
Procarbazine hydrochloride	Possible mechanism is through the inhibition of trans-methylation of methionine into transfer-RNA (t-RNA) thus inhibiting protein synthesis [25]
Lomustine	Nitrosourea that works as an alkylating agent [9]
Vincristine sulfate	Inhibits the formation of microtubules by binding to tubulin which leads to mitosis arrest. It also is able to block glutamic acid utilization and thereby interfere with the synthesis of nucleic acids and proteins [26]

Medication

Mechanism of action

Procarbazine hydrochloride

Possible mechanism is through the inhibition of trans-methylation of methionine into transfer-RNA (t-RNA) thus inhibiting protein synthesis [25]

Lomustine

Nitrosourea that works as an alkylating agent [9]

Vincristine sulfate

Inhibits the formation of microtubules by binding to tubulin which leads to mitosis arrest. It also is able to block glutamic acid utilization and thereby interfere with the synthesis of nucleic acids and proteins [26]