Significant interacting residues of CSF1R and their functions
| Interacting binding sites | Functions | References |
|---|---|---|
| Thr663 | Gatekeeper residue | [26, 42] |
| Cys666 | ATP binding site residue | [26] |
| Tyr546, Trp550 | Regulates JMD to maintain an autoinhibitory state | [39] |
| Asp796 | Form the DFG-motif, regulates the activation loop to maintain an autoinhibitory conformation | [8] |
| Met637, Leu588 | Residues of CSF1R specificity | [26, 42] |
| Lys616, Glu633 | Forms salt bridge regulating activation | [34] |
| Leu640, Ile646, Leu769, Leu785, Val596, Cys774, Ile794 | Forms a hydrophobic pocket | [34] |