From:  Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity

Histopathological features of the analyzed samples from pulmonary resections

VariablesPulmonary metastasisNumber of patients (%)
Number of metastasesSingle12 (48)
Multiple13 (52)
HistotypeClear cell23 (92)
Sarcomatoid1 (4)
Others1 (4)
LateralityLeft lung7 (28)
Right lung14 (56)
Bilateral involvement4 (16)
Nodal involvementYes3 (12)
No3 (12)
Unknown (not resected)21 (84)
Necrosis017 (68)
1 (+)3 (12)
2 (++)2 (8)
3 (+++)3 (12)