From:  Effect of vitamin D supplementation on inflammatory markers and total antioxidant capacity in breast cancer women using a machine learning technique

Change in biomarkers of serum after supplementation of vitamin D in breast cancer patients

BiomarkersPlaceboVitamin DAbsolute treatment effecta
Baseline2 MonthsPcBaseline2 MonthsPcPlaceboVitamin DPb
25(OH)D (ng/mL)15.3 ± 2.213.4 ± 2.20.5928 ± 2.639 ± 3.50.004*–1.9 ± 0.911 ± 3.10.001*
TNF-α (pg/mL)32.6 ± 825.6 ± 3.20.1913.4 ± 1.114.5 ± 1.60.967 ± 2.11.1 ± 2.10.18
TGF-β (pg/mL)123.4 ± 9133.8 ± 100.24293.8 ± 48.8288 ± 42.90.8410.4 ± 7.1–5.6 ± 33.40.64
TAC (U/mL)45.2 ± 11.529.2 ± 8.30.001*48.9 ± 13.363.5 ± 13.30.004*–16 ± 8.414.6 ± 8.90.017*
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a Absolute treatment effect is the absolute change from baseline to follow-up in the treatment group minus the absolute change from baseline to follow-up in the placebo group; b P values for differences between the treatment and placebo groups; c P values for difference between baseline visit and post-intervention values; * P value < 0.05; values are mean ± SD