Targets of succinylation in the mitochondria
| Protein | Sites | Pathway | Model | Reference |
|---|---|---|---|---|
| Carbamoyl phosphate synthase 1 (CPS1) | - | Urea cycle | Mouse liver | [45] |
| Ornithine transcarboxylase (OTC) | K88 | |||
| SDH subunit A (SDHA) | K182 | TCA cycle | SIRT5 KO mouse adipose-derived mesenchymal stem cells (ADMSCs) | [57] |
| 2-Oxoglutarate dehydrogenase E1 (OGDH) | K276 | |||
| Malate dehydrogenase 2 (MDH2) | K239, K307, K335 | |||
| Citrate synthase (CS) | - | SIRT5 KO mouse brain after subarachnoid haemorrhage (SAH) | [54] | |
| ATP synthase | - | |||
| Uncoupling protein-1 (UCP-1) | K56, K73, K151, K67 | Thermogenesis Glutamine metabolism | SIRT5 KO mouse BAT | [58] |
| Glutamate dehydrogenase 1 (GLUD1) | K90, K480 | |||
| SDHA | K179, K485 | |||
| SDHB | K169 | |||
| Mitochondrial trifunctional enzyme subunit alpha (ECHA) | K351 | Fatty acid oxidation | SIRT5 KO mouse heart | [50] |
| SDHA | K179 K335 | Mitochondrial respiration | SIRT5 KO mouse heart after TAC | [59] |
| Hydroxyaryl-CoA dehydrogenase subunit A (HDHA) | K351 | |||
| Very long-chain acyl-CoA dehydrogenase (VLCAD) | K299, K482, K492, K507 | Fatty acid oxidation | VLCAD KO and SIRT5 KO mouse | [60] |
| SDHA | K547 | Mitochondrial respiration | Human renal cell carcinoma | [61] |
| IDH2 | - | Reduced form of NAD phosphate (NADPH) metabolism | SIRT5 KO mouse breast cancer cells | [62] |
| Glutaminase (GLS) | K311 | Glutamine metabolism | Human pancreatic cancer cells | [63] |
| K164 | Human breast and lung cancer cells | [64] | ||
| Serine hydroxymethyltransferase-2 (SHMT2) | K280 | Anti-oxidant mechanism | Human colorectal carcinoma | [65] |
| Mitochondrial antiviral signalling protein (MAVS) | K7 | Interferon response | SIRT5 KO mouse MEFs Human Embryonic Kidney 293 (HEK293T) | [66] |
-: no data