Targets of cytoplasmic succinylation
| Protein | Sites | Pathway | Model | Reference |
|---|---|---|---|---|
| SOD1 | K123 | Anti-oxidant mechanism | Lung tumour cells HEK293T | [83] |
| ACOX1 | K89, K437, K488, K500, K537 | Fatty acid oxidation | SIRT5 KO mouse Human hepatocellular carcinoma (HCC) cancer samples | [84] |
| PKM2 | K433 | Glycolysis | Human cancer cells Colon cancer specimens | [85] |
| K311 | PKM2-HIF-1α-IL-1β | Bone marrow-derived macrophages (BMDMs) | [86] | |
| K498 | Anti-oxidant mechanism | Human lung carcinoma cells | [87] | |
| ENO1 | K80, K81 K355 | Cell proliferation | Breast cancer cells | [28] |
| PGAM1 | K99 | Glycolysis | Human pancreatic cancer cells | [27, 88] |
| LDHA | K118 | Prostate cancer cells | [89] | |
| K222 | Human gastric cancer (GC) samples | [90] | ||
| TAGLN2 | K40 | Cytoskeletal rearrangement | Human glioblastoma samples and cells | [91] |
| FBN1 | K672 | Transforming growth factor β1 (TGFβ1)-PI3K/Akt | Huma primary gastric adenocarcinoma samples | [92] |
| S100A10 | K47 | Tumour migration and invasion | Human GC tissues | [93] |