Exploration of Targeted Anti-tumor Therapy

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t3

From: Post-translational modulation of cell signalling through protein succinylation

Table 3

Targets of succinylation in the nucleus

Protein	Sites	Protein	Model	Reference
H2A	K9, K36, K95	-	In vitro study	[112]
H2B	K34	Destabilised nucleosome	In vitro study and budding yeast	[113]
H2B	K5, K43, K46, K85, K108, K116, K120	-	Review	[114]
H3	K122	Destabilised nucleosome Active transcription	Breast cancer cells	[115]
		Active transcription	Human pancreatic cancer cells	[27]
		Active hepatitis B virus (HBV) transcription	HBV-infected human liver	[41]
		Active hepatitis B virus (HBV) transcription	HBV-infected human hepatocytes	[116]
	K79	Active transcription	Human glioblastoma cells	[29]
		Active transcription β-catenin stabilization	Pancreatic cancer cells	[117]
		Active HBV transcription	Chimeric mice, HBV-infected human hepatocytes	[118]
	K9, K14, K23, K27, K56	-	In vitro study	[36, 112, 114]
H4	K77	DNA unwrapping Active transcription	In vitro study	[109]
H4	K12, K31, K79, K91	-	In vitro study	[111, 112]

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