Exploration of Targeted Anti-tumor Therapy

Table 1

Examples of translationally regulated genes with relevance to mature B-cell neoplasms

Gene(s)	Protein function	Association with B-cell neoplasms	Evidence for translational control via eIFs	Refs
MYC	Cell growth	Translocations are a hallmark of Burkitt’s lymphoma Recurrent mutations in double/triple hit DLBCL Increased expression following BCR stimulation is associated with increased mRNA translation	Inhibition of eIF4A reduces MYC expression in B-cell lymphoma cell lines Inhibition of eIF4E reduces MYC mRNA translation and nuclear export in DLBCL cell lines	[96, 101–104]
MCL1	Cell survival (anti-apoptotic)	Expression induced following BCR stimulation	Inhibition of eIF4A reduces MCL1 expression in B-cell lymphoma cell lines	[103]
BCL2	Cell survival (anti-apoptotic)	Translocations are a hallmark of FL Recurrent translocations in GCB-DLBCL and double/triple hit DLBCL	Inhibition of eIF4E reduces BCL2 mRNA translation and nuclear export in DLBCL cell lines	[101]
CCND1	Cell cycle progression	Translocations are a hallmark of mantle cell lymphoma	Inhibition of eIF4A reduces cyclin D1 expression in B-cell lymphoma cell lines	[103]
BCL6	Transcriptional repression	Recurrent translocations in double/triple hit DLBCL	Inhibition of eIF4E reduces BCL6 mRNA translation and nuclear export in DLBCL cell lines	[101]
CARD11, BCL10, MALT1	CBM complex components which control NF-κB activation	Recurrent mutations in subset of ABC-DLBCL Mediates NF-κB activation downstream of BCR	Inhibition of eIF4A reduces CBM complex expression in DLBCL cell lines	[102]