From:  Cola rostrata K. Schum. constituents induce cytotoxicity through reactive oxygen species generation and mitochondrial membrane depolarisation

IC50 values for the cytotoxic effects of 2AFH fractions on HeLa and MRC5-SV2 cells following 24 h and 48 h treatments (n = 3)

2AFH fractionsHeLa (IC50, μg/mL)MRC5-SV2 (IC50, μg/mL)
24 h48 h24 h48 h
2AFH2560.9 ± 7.739.6 ± 7.241.8 ± 12.027.9 ± 4.3
2AFH4025.5 ± 3.418.9 ± 0.424.6 ± 2.826.7 ± 4.7
2AFH5031.3 ± 4.414.9 ± 0.826.4 ± 4.512.8 ± 1.0
2AFH6024.6 ± 2.118.5a26.4 ± 4.715.9 ± 0.9
2AFH8024.3a27.0 ± 6.9b22.6 ± 3.1b16.4 ± 0.6
2AFH10083.2 ± 3.635.4 ± 1.247.5 ± 1.530.9 ± 3.6
2AFH100MeOHND104.0 ± 15.2ND80.4 ± 11.2
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ND: not determined. a value is for n = 1, and b value is for n = 2