Exploration of Targeted Anti-tumor Therapy

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From: CD99 tumor associated antigen is a potential target for antibody therapy of T-cell acute lymphoblastic leukemia

Table 1

The direct effects of anti-CD99 mAbs in T-ALL

Antibody name	Isotype	Epitope	Effect on T-ALL	Effect on normal cells
DN16	mIgG1	LPDNENKK	Induces apoptosis	Not performed
0662	mIgG3	GSFSDADLA	Induces apoptosis	Not performed
12E7	mIgG1	DGEN	No apoptosis	Not performed
D44	mIgM	Not reported	No apoptosis	Not performed
Ad20	mIgM	Not reported	Induces apoptosis	No apoptosis
10A1	hIgG1^※	ENDDPRPPNPPKPM	Induces apoptosis	No apoptosis
YG32	mIgG	RPPNPPK	No apoptosis Induces homotypic aggregation	Not performed
MT99/3	mIgG2a	Not reported	No apoptosis Induces homotypic aggregation	Not performed
MT99/1	mIgM	Not reported	Induces homotypic aggregation and apoptosis	Not performed
MT99/2	mIgM	Not reported	No homotypic aggregation and no apoptosis	Not performed

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^※ Tetravalent antibody. hIgG1: human IgG1