From:  Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer
 

Characteristics of TAM-resistant breast cancer cell lines derived from MCF-7

Parental cell lineTAM resistant derivative
Cell lineMethod of induction of TAM resistance
WT MCF-7
(oestrogen-dependent, TAM-sensitive)		TAMr 1Chronic TAM exposure (12 months)
TAMr 2Chronic TAM exposure (21 months)
MCF-7-5CLong-term oestrogen deprivation
MCF-7-WS8Long-term oestrogen deprivation
MCF-7/LCC1
(oestrogen-independent, endocrine therapy responsive)		LCC2Stepwise selection against TAM
LCC9Stepwise selection against fulvestrant
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