Clinical studies using test systems based on primary tumor cells (the information was obtained using the website ClinicalTrials.gov)
| Clinical trial identifier | Estimated enrollment | Cancer type | Cell culture type | Purpose |
|---|---|---|---|---|
| NCT04298489 | 40 | Gastrointestinal | Primary cell | Explore the clinical feasibility of using the primary cell culture system to guide gastrointestinal cancer chemotherapy (5-fluorouracil, oxaliplatin, irinotecan). |
| NCT04797676 | 20 | Pancreatic ductal adenocarcinoma | Primary cell | Investigate the difference in the success rate of culturing primary cells obtained by endoscopic ultrasound-guided fine-needle biopsy wet suction technique and surgery. |
| NCT04342286 | 20 | Kidney cancer | Primary cell (organoid culture) | To establish a sustainable human kidney tumor 3D Matrigel culture system with a stable phenotype. |
| NCT05813509 | 30 | Ovarian cancer | Primary cell (organoid culture) | Use organoids cultured from patients’ own ovarian cancer tissues as models, and screen potential clinical therapeutic drugs (paclitaxel, carboplatin, lobaplatin, doxorubicin, etc.). |
| NCT02646228 | 500 | Metastatic cancer | Primary cell | Establishment of patient-derived cancer cell models to interrogate novel molecular targets in metastatic cancer. |