From:  DNA damage targeted therapy for advanced breast cancer

Surrogate definitions of intrinsic subtypes of BC [10, 12]

Intrinsic subtypeImmunohistochemical phenotypeFrequency (%)
Luminal A-likeHigh ER and PgR; HER2-negative; low proliferation rates; typically low grade; low Ki-67 index60–70%
Luminal B-like HER2-negativeER-positive, but ER and PgR expression lower than in luminal A-like; HER2-negative; higher grade; high Ki-67 index10–20%
Luminal B-like HER2-positiveER-positive, but ER and PgR expression lower than in luminal A-like; HER2-positive; higher grade; high Ki-67 indexBoth 13–15%
HER2-positive (non-luminal)HER2-positive; ER and PgR absent; high grade; high Ki-67 index
TNBCER and PgR absent, HER2-negative; higher grade; high Ki-67 index10–15%
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ER: estrogen receptor; HER2: human epidermal growth factor receptor 2; PgR: progesterone receptor; BC: breast cancer; TNBC: triple-negative breast cancer