Distribution of druggable genetic alterations in patients of different race, age, gender and smoking history
| Type of genetic alteration | Gene | Frequency | Race | Age | Gender | Smoking history | References |
|---|---|---|---|---|---|---|---|
| Mutations | EGFR | 10−20% in non-Asians, up to 60−70% in Asians | More common in Asians | L858R substitution is particularly common in elderly patients | More common in females | More common in non-smokers | [33, 37, 59] |
| ERBB2 (HER2) | 2−3% | More common in young patients | More common in females | More common in non-smokers | [60–62] | ||
| BRAF V600 | 1−2% | More common in elderly patients (?) | More common in females | More common in non-smokers | [62–65] | ||
| KRAS G12C | 10−15% | More common in smokers | [5, 66] | ||||
| MET | 2−3% | More common in elderly patients | More common in females | More common in non-smokers | [67, 68] | ||
| Rearrangements | ALK | 4−5% | More common in young patients | More common in females | More common in non-smokers | [69] | |
| ROS1 | 1−2% | More common in young patients | More common in females | More common in non-smokers | [69, 70] | ||
| RET | 2−4% | More common in young patients (?) | More common in females | More common in non-smokers | [71] | ||
| NTRK1−3 | 0.2% | More common in young patients | More common in females | More common in non-smokers | [72, 73] |
(?): not enough evidence. The blank cells indicate lack of association or absence of relevant information