Exploration of Targeted Anti-tumor Therapy

Cases	Primary disease	Sites of cancer at treatment initiation	Indication; treatment line	Treatment	Pre-existing comorbidities	Baseline medications
Case 1	Melanoma (resected stage 3A)	N/A	Adjuvant	Pembrolizumab, 6-weekly	Coeliac disease, osteoarthritis, hiatus hernia, rheumatoid arthritis	Nil
Case 2	Non-small cell lung cancer	Lung, bone, liver, leptomeningeal	Palliative; first-line	Pembrolizumab/Carboplatin/Pemetrexed, 3-weekly	high cholesterol, pulmonary embolus	Atorvastatin, apixaban, paracetamol, levetiracetam
Case 3	Renal cell carcinoma (clear cell)	Lung, bone	Palliative; third-line	Nivolumab, 4-weekly	Type 2 diabetes mellitus, spinal stenosis	Oramorph, zopiclone, lactulose

Cases

Primary disease

Sites of cancer at treatment initiation

Indication; treatment line

Treatment

Pre-existing comorbidities

Baseline medications

Case 1

Melanoma (resected stage 3A)

N/A

Adjuvant

Pembrolizumab, 6-weekly

Coeliac disease, osteoarthritis, hiatus hernia, rheumatoid arthritis

Nil

Case 2

Non-small cell lung cancer

Lung, bone, liver, leptomeningeal

Palliative; first-line

Pembrolizumab/Carboplatin/Pemetrexed, 3-weekly

high cholesterol, pulmonary embolus

Atorvastatin, apixaban, paracetamol, levetiracetam

Case 3

Renal cell carcinoma (clear cell)

Lung, bone

Palliative; third-line

Nivolumab, 4-weekly

Type 2 diabetes mellitus, spinal stenosis

Oramorph, zopiclone, lactulose