Similarity and differences in features of SMZL, HCL, and SDRPL
| Features | Type of feature | SMZL | HCL | SDRPL |
|---|---|---|---|---|
| Demographics | Incidence | 0.13/100,000 | 0.4/100,000 | ? |
| Median age | 65–69 | 55–63 | 70 | |
| M:F ratio | 1:1.1 to 1:1.85 | 3:1 to 4:1 | 1.6:1 to 2.4:1 | |
| Immunophenotype | CD25 | + | ++ | - |
| CD27 | ++ | -- | - | |
| CD5 | + | - | - | |
| CD200 | - | ++ | - | |
| Outcome | Need for treatment | 70% | Yes | 50% |
| Transformation | 10–20% into DLBCL | 5–6% | Rarely |
+: indicates positive; ++: indicates strong positive; -: indicates negative; --: indicates strong negative; ?: unknown. SMZL: splenic marginal zone lymphoma; HCL: hairy cell leukaemia; DLBCL: diffuse large B-cell lymphoma; SDRPL: splenic diffuse red pulp lymphoma; M:F: male: female