Anticancer effects of cardamonin in vivo
| Cancers | Cell line | Phenotypic effects | Mechanisms of action | References |
|---|---|---|---|---|
| Breast cancer | MDA-MB-231 | Inhibitory effects on tumor angiogenesis | ↓Bcl-2, ↑Bax, ↑caspase-3, ↓HIF-1a, ↓LDHA | [36] |
| Drug-resistant CSC’s | Inhibited tumor growth and volume | - | [37] | |
| Gastric cancer | BCG-823/5-FU | Reduced tumor growth | - | [50] |
| Leukemia | BALB/c mice | - | ↓CD3, ↓CD11b, ↓Mac-3, ↑CD19 | [53] |
| Lung cancer | NSCLC A549, H460 | Reduced cell proliferation and metastatic abilities | ↓Ki-67, ↓mTOR, ↓Akt | [60] |
| LLC cells | Suppressed lung metastasis and tumoral growth | ↓mTOR | [62] |