From:  Harnessing endoscopic ultrasound-guided radiofrequency ablation to reshape the pancreatic ductal adenocarcinoma microenvironment and elicit systemic immunomodulation

List of current clinical trials incorporating EUS-RFA into the clinical management of pancreatic adenocarcinoma

Study title for RCTNCT numberConditionsInterventionsLocation
EUS-RFA for pancreatic neoplasmsNCT03218345

  • Pancreatic neoplasms

Procedure: EUS-RFAHong Kong, China
EUS-RFA for unresectable pancreatic cancerNCT04310111

  • PDAC

Procedure: EUS-RFAChina
EUS-RFA for unresectable PDACNCT03772756

  • Pancreatic adenocarcinoma non-resectable

Procedure: EUS guided RFA
Radiation: chemoradiotherapy		China
EUS-RFA for treatment of PDACNCT05723107

  • Pancreatic cancer

Drug: chemotherapy
Device: EUS-RFA		NY, USA
Evaluation of safety and feasibility of EUS-RFA for solid pancreatic neoplasmsNCT03435770

  • Pancreatic neoplasms

Device: EUS-RFA needleSingapore
Evaluation of EUS-RFA for the management of pancreatic tumors, ERASE StudyNCT05961982

  • Pancreatic neoplasm

Procedure: EUS-guided fine-needle aspiration
Procedure: EUS-RFA		Ohio, USA
A single-arm phase II study to evaluate the safety and efficacy of combination systematic chemotherapy and multiple rounds of EUS-RFA in pancreatic cancerNCT04990609

  • PDAC

Device: EUS-RFA
Drug: neoadjuvant chemotherapy (NAC)		Houston, USA
EUS-RFA of not-resectable pancreatic cancerNCT04164992

  • PDAC

Device: EUSRA electrode needle connected to a radiofrequency generator (VIVA RF Generator; STARmed, Seoul, S. Korea)Italy
Safety and efficacy of an ablation catheter for the treatment of pancreatic premalignant cyctic lesionsNCT03417843

  • Pancreatic cancer

  • Pancreatic neuroendocrine tumor

  • Pancreatic Cyst

Device: EUSRA RF electrodeIsrael
Trial comparing EUS-RFA vs. EUS-guided celiac plexus neurolysisNCT03152487

  • Pancreatic adenocarcinoma

  • Pancreatic neoplasms

  • Celiac plexus neurolysis

  • RFA

Orlando, USA
EUS-coeliac plexus block vs. RFA in pain relief of patients with malignancyNCT04809935

  • Cancer of pancreas

  • Pancreatic neoplasms

Drug: 98% dehydrated alcohol
Device: 19 G EUSRA needle, Taewoong Medical, Korea		Hong Kong, China
Efficacy and safety of RFA in pancreatic neuroendocrine and cystic tumorNCT02330497

  • Pancreatic tumor

  • Endocrine tumor

  • Neoplasms, cystic, mucinous, and serous

Procedure: RFA under EUSFrance
EUS RFA, database repositoryNCT04693754

  • Pancreatic neoplasm

Procedure: RFA under EUSIndiana, USA
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RCT: randomized clinical trial; EUS-RFA: endoscopic ultrasound-guided radiofrequency ablation; PDAC: pancreatic ductal adenocarcinoma; FNA: fine needle biopsy