General characteristics of studies on the role of NLR in tCa staging
| Reference | Sample size | Study design | Year of publication | Country | Histopathology | Cut off value of NLR | Seminomatous tCa | Outcome |
|---|---|---|---|---|---|---|---|---|
| Gokcen et al. [33] | 121 | Retrospective cohort | 2018 | Turkey | TGCT | 2.25 | - | No significant difference was found between patients in different stages according to their NLR values. |
| Şahin et al. [47] | 291 | Cross-sectional retrospective | 2019 | Turkey | tCa | 3.16 | - | There was no association between NLR and different tumor stages. |
| Arda et al. [26] | 182 | Retrospective cohort | 2020 | Turkey | TGCT | 1.78 | 46.60% | Tumor stage was not different between patients with different values of NLR. |
| Horsanali et al. [36] | 128 | Retrospective cohort | 2017 | Turkey | TGCT | 3.72 | 44.80% | No significant correlation was found between NLR value and tumor stage. |
| Yıldırım et al. [52] | 21 | Retrospectivecohort | 2013 | Turkey | tCa | - | 47.61% | There was no significant correlation between NLR and tCa staging. |
| Kölükçü et al. [41] | 17 | Retrospective cohort | 2017 | Turkey | tCa | - | 17.64% | The NLR value was not different between different tumor stages. |
| Imamoglu et al. [4] | 112 | Retrospective cohort | 2019 | Turkey | TGCT | 3.21 | 58.92% | There was a significant difference in NLR between stage I and advanced stages. |
| Jankovich et al. [38] | 103 | Retrospective cohort | 2017 | Slovakia | TGCT | 4 | 39.80% | There was a significant correlation between NLR and tumor stage. |
| Karakaya et al. [39] | 40 | Retrospective cohort | 2021 | Turkey | TGCT | - | 22.50% | Statistically significant positive correlations were found between tumor stage and NLR. |
| Olcucu et al. [44] | 99 | Retrospective cohort | 2020 | Turkey | TGCT | 3.21 | 45.45% | Patients with advanced-stage cancer had higher values of NLR in comparison with those in lower stages. |
| Pęksa et al. [45] | 180 | Retrospective cohort | 2021 | Poland | TGCT | 3.56 | 53.90% | NLR was significantly higher in patients with stage II/III tumors compared to those with stage I. |
| Tan et al. [2] | 160 | Retrospective cohort | 2019 | Singapore | tCa | 3 | 63.80% | Patients with advanced stages had higher values of NLR than those in lower stages. |
tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio