General characteristics of studies on the association of NLR with nodal or distant metastases in tCa
| Reference | Sample size | Study design | Year of publication | Country | Histopathology | Cut off value of NLR | Seminomatous tCa | Outcome |
|---|---|---|---|---|---|---|---|---|
| Yigit et al. [51] | 146 | Retrospective cohort | 2018 | Turkey | tCa | 3.11 | 36.30% | High level of NLR was associated with the risk of metastasis. |
| Bolat et al. [29] | 53 | Retrospective cohort | 2017 | Turkey | TGCT | 3.35 | 50.90% | Elevated NLR could predict lymph node involvement. |
| Ilktac et al. [37] | 61 | Retrospective cohort | 2020 | Turkey | TGCT | 2.56 | 59.00% | NLR was significantly higher in patients with non-localized TGCT compared to those with localized TGCT. |
| Horsanali et al. [36] | 128 | Retrospective cohort | 2017 | Turkey | TGCT | 3.72 | 44.80% | Elevated NLR was significantly related to metastasis. |
| Köşeci et al. [43] | 72 | Retrospective cohort | 2021 | Turkey | TGCT | 2.5 | 43.00% | Elevated NLR could predict metastasis. |
| Pęksa et al. [45] | 180 | Retrospective cohort | 2021 | Poland | TGCT | 3.56 | 53.90% | Elevated NLR could predict the presence of nodal or distant metastases. |
| Bauzá Quetglas et al. [46] | 80 | Retrospective cohort | 2020 | Spain | tCa | 2.25 | 62.50% | NLR had higher levels in patient with non-localized tCa than those with localized tCa. |
| Olcucu et al. [44] | 99 | Retrospective cohort | 2020 | Turkey | TGCT | 3.21 | 45.45% | Elevated NLR could predict metastasis and low mean survival time. |
| Tan et al. [2] | 160 | Retrospective cohort | 2019 | Singapore | tCa | 3 | 63.80% | High levels of NLR were associated with metastasis and poorer CSS. |
| Arda et al. [26] | 182 | Retrospective cohort | 2020 | Turkey | TGCT | 1.78 | 46.60% | There was no significant association between metastasis with NLR of patients. |
| Jankovich et al. [38] | 103 | Retrospective cohort | 2017 | Slovakia | TGCT | 4 | 39.80% | No significant correlation was found between metastasis with NLR. |
| Kopru et al. [42] | 80 | Retrospective cohort | 2019 | Turkey | tCa | - | 51.51% | NLR had no statistically significant correlation with metastasis and the presence of lymphovascular invasion. |
| Başer and Aras [28] | 83 | Retrospective cohort | - | Turkey | TGCT | 2.27 | 60.00% | There was no significant association between NLR and metastasis or lymph node involvement. |
tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio