From:  Diagnostic and prognostic role of NLR in testicular cancer

General characteristics of studies on the association of NLR with survival in tCa

ReferenceSample sizeStudy designYear of publicationCountryHisto
pathology		Cut off value of NLRSeminomatous tCa
Outcome
Arıman and Merder [27]152Retrospective cohort2021TurkeytCa2.3952.60%Patients with good prognosis had statistically significant lower NLR than those with intermediate and poor prognosis.
Tan et al. [2]160Retrospective cohort2019SingaporetCa363.80%High levels of NLR were associated with poorer CSS.
Fankhauser et al. [31]146Retrospective cohort2018SwitzerlandTGCT4.525.34%NLR was an independent predictor of OS.
Olcucu et al. [44]99Retrospective cohort2020TurkeyTGCT3.2145.45%Elevated NLR could predict metastasis and low mean survival time.
Herraiz-Raya et al. [35]164Retrospective cohort2019SpainTGCT450.00%There was significant correlation between NLR and residual disease after chemotherapy and mean survival time of tCa patients.
Yang et al. [50]2008–2016Retrospective
cohort		2019ChinatCa2.66-High NLR was significantly associated with an elevated risk for disease progression.
Karakaya et al. [39]40Retrospective
cohort		2021TurkeyTGCT-22.50%NLR was a strong predictor of response to chemotherapy in tCa patients.
Bauzá Quetglas et al. [46]80Retrospective cohort2020SpaintCa2.2562.50%Pre-orchiectomy NLR was higher in patients who had adjuvant chemotherapy than those without chemotherapy.
Post-orchiectomy NLR was related to the risk of recurrence and recurrence-free survival.
Selvi and Başar [49]99Retrospective cohort2019TurkeytCa3.2360.00%NLR was found to be significantly higher in patient with bilateral tCa than those with unilateral tCa. High NLR could predict contralateral tumor development.
Arda et al. [26]182Retrospective cohort2020TurkeyTGCT1.7846.60%CSS was not different between patients with different NLR.
Yoshinaga et al. [53]63Retrospective cohort2021JapanTGCT4.127.00%There was no significant association between PFS and OS and NLR.
Pęksa et al. [45]180Retrospective cohort2021PolandTGCT3.5653.90%NLR could not predict progression or relapse in tCa patients.
Bolat et al. [29]53Retrospective cohort2017TurkeyTGCT3.3550.90%Time-to-cancer specific death between patients with different NLR was not significantly different.
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tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio; CSS: cancer-specific survival; OS: overall survival; PFS: progression-free survival