General characteristics of studies on the association of NLR with conventional tumor markers of tCa
| Reference | Sample size | Study design | Year of publication | Country | Histopathology | Cut off value of NLR | Seminomatous tCa | Outcome |
|---|---|---|---|---|---|---|---|---|
| Arda et al. [26] | 182 | Retrospective cohort | 2020 | Turkey | TGCT | 1.78 | 46.60% | B-HCG level was significantly higher in the patients with higher NLR. |
| Horsanali et al. [36] | 128 | Retrospective cohort | 2017 | Turkey | TGCT | 3.72 | 44.80% | Levels of AFP, B-HCG, and LDH were significantly related to NLR level. |
| Olcucu et al. [44] | 99 | Retrospective cohort | 2020 | Turkey | TGCT | 3.21 | 45.45% | NLR was significantly related to LDH level. |
| Bauzá Quetglas et al. [46] | 80 | Retrospective cohort | 2020 | Spain | tCa | 2.25 | 62.50% | No correlation was observed between NLR and conventional tumor markers (AFP and B-HCG). |
tCa: testicular cancer; TGCT: testicular germ cell tumor; NLR: neutrophil to lymphocyte ratio