Overview on miRNA as biomarkers in liquid biopsy for MPM
| Author | Biomarker | Study design | Samples | Role |
|---|---|---|---|---|
| Santarelli et al. 2011 [77] | miR-126 | MPM = 44; AES = 196; HS = 55 | Serum | Diagnosis: MPM vs. AES (sensitivity 73%, specificity 74%) |
| Kirschner et al. 2011 [84] | miR-625 | MPM = 30; AES = 10 | Serum | Diagnosis: MPM vs. AES (sensitivity 70%, specificity 90%) |
| Weber et al. 2012 [88] | miR-103a | MPM = 23; AES = 17 | Blood | Diagnosis: MPM vs. AES (sensitivity 83%, specificity 71%) |
| Weber et al. 2017 [81] | miR-132 | MPM = 21; AES = 21 | Plasma | Diagnosis: MPM vs. AES (sensitivity 86%, specificity 61%) |
| Cavalleri et al. 2017 [87] | miR-103 + miR-30e EVs | MPM = 23; AES = 19 | Plasma | Diagnosis: MPM vs. AES (sensitivity 95.5%, specificity 80%) |