Exploration of Targeted Anti-tumor Therapy

Author	Biomarker	Study design	Samples	Role
Santarelli et al. 2015 [78]	Methylated TM	MPM = 45; AES = 99; HS = 44	Serum	Diagnosis: MPM vs. controls (sensitivity 60%, specificity 81%)
Sriram et al. 2014 [91]	DNA integrity index (+ citology)	MPE = 52; OPE = 23	Pleural effusion	Diagnosis: MPM vs. OPE (sensitivity 81%, specificity 87%)
Yoneda et al. 2019 [97]	Podoplanin	MPM = 15	Blood	Diagnosis: CTC-chip vs. CellSearch (sensitivity 63.3%–64.5%); prognosis

Author

Biomarker

Study design

Samples

Role

Santarelli et al. 2015 [78]

Methylated TM

MPM = 45; AES = 99; HS = 44

Serum

Diagnosis: MPM vs. controls
(sensitivity 60%, specificity 81%)

Sriram et al. 2014 [91]

DNA integrity index (+ citology)

MPE = 52; OPE = 23

Pleural effusion

Diagnosis: MPM vs. OPE
(sensitivity 81%, specificity 87%)

Yoneda et al. 2019 [97]

Podoplanin

MPM = 15

Blood

Diagnosis: CTC-chip vs. CellSearch
(sensitivity 63.3%–64.5%); prognosis