From:  Multi-omics tumor profiling technologies to develop precision medicine in multiple myeloma

Prognostic scores for MM based on mutational status and/or GEP

ScoreGenesDatasetsReference
Proliferation index11 genes: TOP2A, BIRC5, CCNB2, NEK2, ANAPC7, STK6, BUB1, CDC2, C10orf3, ASPM, and CDCA1UAMS-TT2
UAMS-TT3		[17]
UAMS70/UAMS1770/17 genes
High risk: over expression of chromosome 1q genes and reduced expression of 1p genes		UAMS[157]
UAMS8080 genesUAMS-TT2
UAMS-TT3		[158]
GSSGood-risk: allele-specific CAN genomic markersIFM/DFCI2009 study
CoMMpass		[155]
HM1919 genes (15 risk and 4 protective)HM
UAMS-TT2		[159]
CTA (cancer testis antigen)87 genes
Most relevant genes: MAGEC1, MAGEB2, SSX1, MAGEA6, CDCA1, MAGEA9, CTAG2		HOVON65/GMMG-HD4
APEX/SUMMIT/CREST		[160]
CICentrin, pericentrin, γ-tubulinUAMS-TT2
Bortezomib trial
Mayo Clinic cohort
HMCLs		[161, 162]
IFM1515 genes (cell cycle genes)IFM-G[163]
MRCIX6 (aka HZCDC)BUB1B vs. HDAC3
CDC2 vs. FIS1 RAD21 vs. ITM2B		Medical Research Council-IX (MRC-IX)[156]
GPI50 PI50 genes
Poor prognosis: gain of 1q21 or deletion of 13q14.3 Good prognosis: gain of chromosome 9, 15 or 19		HM1 (E-MTAB-316)
HM2 (E-MTAB-317)
E-GEOD-2658
GSE4581		[164]
EMC-92 (SKY92)92 genes
Most relevant genes: FGFR3 and BIRC5		HOVON-65/GMMG-HD4
TT2, TT3, MRC IX, APEX		[165–167]
HM-metascoreAlgorithmic integration of International Stating System (ISS), cytogenetics, gene-expression, event-free survival (EFS), overall survival (OS), proliferation index, target gene expression of aurora kinase A, FGFR3, IGF1RHM (E-MTAB-372)
UAMS-TT2
MMRC (Multiple Myeloma Research Consortium data)		[168]
8-gene signatureATF2, CCND2, CFLAR, DDX17, HSPA1A, RIT1, RNF148, WHSC1GSE16791[169]
Spike band score53 (35 bad prognosis and 18 good prognosis)HM (E-MTAB-362)
UAMS-TT2 (GSE2658)
HMCLs (E-TABM-937 and E-TABM-1088)		[170]
HMCL7/HMCL67 bad prognostic genes: TEAD1, CLEC11A, LRP12, MMSET, FGFR3, NUDT11, and KIAA1671
6 genes: FSTL5, GAGE1, GAGE12, BCHE, HOOK3, and
LOC283352		HMCLs (E-TABM-937 and E-TABM-1088)[171]
CINGECS160 genesGSE26849
GSE26760
GSE2658 UAMS
GSE9782 APEX
GSE19784 HOVON		[172]
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CAT: cancer testis antigen