Drug response-scores based on GEP
| Score | Genes | Datasets | Reference |
|---|---|---|---|
| 8-gene signature (dexamethasone/ thalidomide) | ATF2, CCND2, CFLAR, DDX17, HSPA1A, RIT1, RNF148, WHSC1 | GSE16791 | [169] |
| DM (DNMTi) | 47 genes | E-MTAB-372HMCLs | [200] |
| M3P (PIs and IMiDs) | 47 genes in del17p | German MM study group (DSMM) | [177–179] |
| DRP (drug response prediction, melphalan and bortezomib) | GSE2658 (TT2/TT3a) GSE19784 (HOVON)GSE68871 (GIMEMAMMY-3006)GSE9782 (APEX) | [196] | |
| IMiD-14 | 14 poor prognosis genes: XPO1, DDR2, TRAF3IP3, FAIM310 good prognosis genes: IL5RA, TNFRSF7, AMPD1, ENO2, ITGA6, FLJ22531, LAMA5, PGRMC2, SLC39A14, KIAA0247 | GSE24080 GSE57317GSE19784 (HOVON65/GMMG-HD4) | [201] |
| HA (HDACi) | 37 genes | E-MTAB-372 GSE2658E-TABM-937 and E-TABM-1088 (HMCLs) | [202] |
| DNMTi/HDACi(decitabine/quisinostat) | 25/62 genes | E-MTAB-3178 | [203] |
| VTD response (Bortezomib-Thalidomide-Dexamethasone) | 5 genes: ACTR2, BAI2, ANK3, GALNT5, GLT1D1 | GSE55145 GSE9872 | [204] |
| DR (DNA repair, DNA damage agents) | 17 bad prognostic5 good prognostic | GSE24080E-MTAB-372 | [27] |
| EZ (EZH2 inhibitor) | 15 genes | E-TABM-93E-TABM-1088 | [205] |