Exploration of Targeted Anti-tumor Therapy

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From: Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study

Table 1

Parameter description and their baseline values with references

Parameters	Definition	Value	Reference
α	Net calcium influx rate through plasma membrane	0.04 μM/s	[38]
β	Maximum SOCE influx rate	0.520 μM/s	estimated
γ	Maximum influx of Ca²⁺ through TRPC1 channel	0.0001/s	estimated
δ	[Ca²⁺]_ER leaking rate	0.0014/s	estimated
ξ	Ca²⁺ export through NCX	7/s	estimated
p₁	Maximal flux through IP₃R2 channel	0.01747 μM/s	estimated
q₁	IP₃R₂ channel’s half-saturation constant	0.0518 μM	estimated
p₂	Maximal flux through SERCA1 channel	3.6926 μM/s	estimated
q₂	SERCA1 channel’s half-saturation constant	0.1 μM	[39]
p₃	Maximal flux through PMCA2 channel	7.34 μM/s	[34]
q₃	PMCA2 channel’s half-saturation constant	1.5 μM	[34]
c_es	Calcium concentration in extracellular space	1000.1812 μM	[40]
k_s	STIM1 ER Ca²⁺ affinity	50 μM	[34]
τ_s	SOCE timescale	30.1752 s	[34]

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