Parametric recalibration table: the table describes the possible mechanisms to restore CRD under different parametric conditions. Here Doxo 1, Doxo 2, Doxo 3 denotes the categories when the baseline parameter set is increased by 25%, 50%, 75% respectively
| Category | Parametric variation | Possible mechanism of restoration |
|---|---|---|
| Doxo 1 | Single paramer variation | 1. Decrease calcium influx rate through TRPC1 channel (γ) |
| 2. Increase SOCE timescale (τs) | ||
| 3. Decrease net calcium influx rate through plasma membrane (α) | ||
| 4. Decrease extracellular calcium concentration (ces) | ||
| Doxo 2 | Single parameter variation | 1. Decrease TRPC1 calcium influx rate (γ) |
| 2. Decrease extracellular calcium concentration (ces) | ||
| Doxo 3 | Double parameter variation | 1. Decrease SOCE flux rate (β) by 20% & decrease TRPC1 calcium influx rate (γ) |
| 2. Decrease SOCE flux rate (β) by 20% & increase SOCE timescale (τs) | ||
| 3. Decrease SOCE flux rate (β) by 20% & decrease SERCA1 channel’s half-saturation constant (q2) | ||
| 4. Decrease SOCE flux rate (β) by 20% & decrease extracellular calcium concentration (ces) |