Multivariable analyses for OS
| Clinical parameter | Univariate cox regression | Multivariate cox regression | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | Exponentiation of the B coefficient (EXP B, 95% CI) | P-value | |
| Gender (male vs. female) | 0.72 (0.30–1.64) | 0.4115 | ||
| PS-ECOG (≥ 2 vs. < 2) | 2,43 (1.19–10.56) | 0.0226 | 0.37 (0.12–1.14) | 0.0840 |
| Age (≥ 70 vs. < 70) | 1.44 (0.70–2.98) | 0.3195 | ||
| Histotype (squamous vs. non-squamous) | 1.08 (0.53–2.21) | 0.8328 | ||
| Smoke (yes vs. no) | 0.38 (0.17–3.95) | 0.8074 | ||
| BM (no vs. yes) | 3.28 (1.73–8.28) | 0.0009 | 0.19 (0.05–0.78) | 0.0222 |
| Pulmonary metastases (no vs. yes) | 1.08 (0.36–3.23) | 0.8845 | ||
| Liver metastases (no vs. yes) | 0.45 (0.11–1.20) | 0.0984 | ||
| Cerebral metastases (no vs. yes) | 0.78 (0.20–2.85) | 0.6751 | ||
| Adrenal metastases (no vs. yes) | 0.66 (0.22–1.62) | 0.3124 | ||
| Lymph nodes metastases (no vs. yes) | 1.29 (0.53–3.33) | 0.5502 | ||
| Pleural metastases (no vs. yes) | 0.58 (0.24–1.21) | 0.1368 | ||
| Maximum lesion diameter (cut-off = 6.3 cm) | 0.80 (0.35–1.86) | 0.6097 | ||
| Sum of the 5 major lesions diameters (cut-off = 14.3 cm) | 1.35 (0.46–4.31) | 0.5438 | ||
| Intrathoracic vs. extrathoracic disease | 0.40 (0.17–0.82) | 0.0136 | 0.12 (0.03–0.52) | 0.0212 |
| Measurable vs. not-measurable disease | 0.09 (0.08–0.44) | < 0.0001 | 0.14 (0.02–0.74 | 0.0216 |
| Number of metastatic sites (≥ 4 vs. < 4) | 2.56 (1.33–8.63) | 0.0106 | 0.65 (0.26–0.87) | 0.0372 |